A Historical Review on the Emerging Preclinical Interest Concerning the Role of Circadian Function in Parkinson's disease.

A Historical Review on the Emerging Preclinical Interest Concerning the Role of Circadian Function in Parkinson's disease.
Brain Res. 2017 Sep 25;:
Authors: Willis GL, Freelance CB
Abstract
The importance of circadian function in the aetiology, progression and treatment of Parkinson's disease is a topic of increasing interest to the scientific and clinical community. While clinical studies on this theme are relatively new and limited in number there are many preclinical studies which explore possible circadian involvement in Parkinson's disease and speculate as to the mechanism by which clinical benefit can be derived by manipulating the circadian system. The present review explores the sequelae of circadian related studies from a historical perspective and reveals mechanism that may be involved in the aetiology and progression of the disease. A systematic review of these studies also sets the stage for understanding the basic neuroscientific approaches which have been applied and provides new direction from which circadian function can be explored.
PMID: 28958865 [PubMed - as supplied by publisher]

Source: Brain Research - September 25, 2017 Category: Neurology Authors: Willis GL, Freelance CB Tags: Brain Res Source Type: research