Integrating TYMS, KRAS and BRAF testing in patients with metastatic colorectal cancer.

CONCLUSION: The TYMS genotypes ins/ins and ins/LOH associate with worst prognosis in mCRC patients under fluoropyrimidine-based chemotherapy. Large prospective studies are needed for validation of our findings.
PMID: 28932083 [PubMed - in process]

Source: World Journal of Gastroenterology : WJG - August 28, 2017 Category: Gastroenterology Authors: Ntavatzikos A, Spathis A, Patapis P, Machairas N, Peros G, Konstantoudakis S, Leventakou D, Panayiotides IG, Karakitsos P, Koumarianou A Tags: World J Gastroenterol Source Type: research