Molecular Signaling Mediated by (Pro)Renin Receptor Blockade Leads to Attenuation of Cardiac Fibrosis in CKD-associated Heart Failure

Chronic kidney disease (CKD) is a major cardiovascular risk factor because of elevated tissue renin-angiotensin system activity in the heart. Although the (pro)renin receptor ((P)RR), specific receptor for renin and (pro)renin, is expressed in the cardiovascular system, its precise function in CKD heart has not yet been elucidated. We investigated the role of (P)RR and underlying molecular mechanism in CKD-associated heart failure using subtotal nephrectomy (STN, 5/6 kidney resection) mice and age-matched control mice treated with handle region peptide (HRP; a peptide which blocks (P)RR).

Source: Journal of Cardiac Failure - September 20, 2017 Category: Cardiology Authors: Akihiro Yoshida, Hiromitsu Kanamori, Genki Naruse, Atsushi Mikami, Masanori Kawasaki, Kazuhiko Nishigaki, Shinya Minatoguchi Source Type: research