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Stable: Since April of 2016 my treatment regimen has been Pomalyst (pomalidomide) and Darzalex (daratumumab), with dexamethasone in the early months. That combination brought my IgG and M-Spike down to the lowest levels seen since diagnosis 14 years ago. M-Spike has not been above 0.5 g/dL since August 2016, and it was 0.5 again last Tuesday. IgG was 536 mg/dL, about where it has been for more than a year. This is wonderful. The Darzalex protocol (with Pomalyst) calls for infusions once per week for 8 doses, then every other week for 8 more, and finally once per month " until disease progression. " So far so good. Darzalex is an infusion that takes several hours, but I get a blood draw, then a visit with the hematologist, and finally the infusion, and I'm still out soon after noon. Some people bring a book to read - I bring my laptop and it's no problem at all. I take it easy for the rest of the day, and life is back to normal the next day. Darzalex is given with some prednisone (or dexamethasone) to reduce the likelihood of an infusion reaction, and I do feel some side effects from that steroid, but none from the Darzalex. Life is good. 28 Infusions of so far - I wonder what my life would have been like without that potent, innovative new medication. Pomalyst has been part of my treatment regimen, 2 mg daily, for all but one of the last nine years. For the past two months my doc and I have tried cutting that to...
Source: Myeloma Hope - Category: Cancer & Oncology Tags: acid reflux daratumumab Darzalex GERD PET scan pomalidomide Pomalyst thyroid Source Type: blogs

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Publication date: Available online 24 January 2020Source: Journal of Genetics and GenomicsAuthor(s): Qianru Huang, Xu Liu, Yujia Zhang, Jingyao Huang, Dan Li, Bin LiAbstractRegulatory T (Treg) cells, a subtype of CD4+ T cells with distinct immunosuppressive, are vital for maintaining immune homeostasis in healthy people. FOXP3 (Forkhead box protein P3), a member of the forkhead–winged-helix family, is the pivotal transcriptional factor of Treg. The expression, post-translational modifications and protein complex of FOXP3 present a great impact on the functional stability and immune plasticity of Treg in vivo. In part...
Source: Journal of Genetics and Genomics - Category: Genetics & Stem Cells Source Type: research
Publication date: Available online 24 January 2020Source: Seminars in Ultrasound, CT and MRIAuthor(s): Supreeta Arya, Saugata Sen, Reena Engineer, Avanish Saklani, Tarun PandeyAbstractHigh-resolution phased array external MRI is the first investigation of choice in rectal cancer for local staging, both in the primary and restaging situations. Use of MRI helps differentiate between those with good prognosis, which can be offered upfront surgery and the poor prognostic cases where treatment intensification is needed. MRI identified poor prognostic factors are threatened or involved mesorectal fascia, T3 tumors with> 5mm e...
Source: Seminars in Ultrasound, CT and MRI - Category: Radiology Source Type: research
Publication date: Available online 24 January 2020Source: Journal of Vascular and Interventional RadiologyAuthor(s): Yumei Yang, Yanfang Zhang, Yumin Wu, Jibing Chen, Bing Liang, Quanhong Chen, Qiuyu Wang, Jialing Lyu, Yong Li, Feng Mu, Duanming DuAbstractPurposeTo evaluate the efficacy and safety of percutaneous argon-helium cryoablation (CA) for hepatocellular carcinoma (HCC) abutting the diaphragm (
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
We report, for the first time, that classical relaxing music decreases the amplitude of the brain pulsatile movements related to cerebral blood flow and mechanical properties of the brain parenchyma, which provides further evidence of the involvement of BTP in emotional reactivity. In addition, we validate the use of TPI as a non-invasive, portable and low cost tool for studies in psychophysiology, with the potential to be implemented as a biomarker in musicotherapy trials notably.
Source: International Journal of Psychophysiology - Category: Psychiatry & Psychology Source Type: research
ConclusionCombined Rendez-vous isthmoplasty is feasible, safe, and effective in experienced hands, giving the surgeon a comprehensive evaluation of the anatomy of the isthmocele, and increasing the odds of a complete resection and restoration of the anatomy 4, 5, 6, 7. In this patient, the procedure was uneventful, without any intra- or postoperative complications, and the symptoms were completely controlled.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Publication date: Available online 24 January 2020Source: Microbial PathogenesisAuthor(s): Mani Divya, Marimuthu Govindarajan, Sivashanmugam Karthikeyan, Elumalai Preetham, Naiyf S. Alharbi, Shine Kadaikunnan, Jamal M. Khaled, Taghreed N. Almanaa, Baskaralingam VaseeharanAbstractβ-Glucan-binding protein (βGBP) is important for the rational expansion of molecular biology. Here, zinc oxide nanoparticle (ZnONP) was synthesized using βGBP from the crab Scylla serrata (Ss-βGBP-ZnONP). Ss-βGBP-ZnONP was observed as a 100 kDa band on sodium dodecyl sulfate polyacrylamide gel and characterized with UV&nd...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Publication date: Available online 25 January 2020Source: Best Practice &Research Clinical HaematologyAuthor(s): Chutima Kunacheewa, Elisabet E. ManasanchAbstractMultiple myeloma, a bone marrow cancer, is preceded by precursor stages called monoclonal gammopathy of unknown significance and smoldering multiple myeloma. Over the past few years, highly effective and safe therapies have been made available to treat multiple myeloma. This represents a major breakthrough and has major therapeutic implications. Treatment for multiple myeloma has evolved to include treatment of precursor stages (early treatment) as these thera...
Source: Best Practice and Research Clinical Haematology - Category: Hematology Source Type: research
Publication date: Available online 25 January 2020Source: Molecular and Cellular EndocrinologyAuthor(s): Naiara A. Herrera, Francine Duchatsch, Lidieli P. Tardelli, Thiago J. Dionísio, Andre L. Shinohara, Carlos F. Santos, Sandra L. AmaralAbstractMicrocirculation maintenance is associated with microRNAs. Nevertheless, the role of microRNAs induced by training in preventing dexamethasone (DEX)-induced microvascular rarefaction remains unknown. The study aim was to investigate if training-induced microRNAs are able to improve microcirculation proteins and prevent DEX-induced microvascular rarefaction. Rats underwent t...
Source: Molecular and Cellular Endocrinology - Category: Endocrinology Source Type: research
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Source: Expert Opinion on Biological Therapy - Category: Drugs & Pharmacology Authors: Source Type: research
ConclusionsMechanical extraction is more effective for extracting fractured implant-prosthetic screws, showing a higher probability of extraction than the conventional method. Prosthetic fixing screws with a smooth shaft and threaded apical area are the easiest to extract.
Source: The Journal of Prosthetic Dentistry - Category: Dentistry Source Type: research
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