Khz-cp (crude polysaccharide extract obtained from the fusion of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis by increasing intracellular calcium levels and activating P38 and NADPH oxidase-dependent generation of reactive oxygen species in SNU-1 cells

Conclusions:
In summary, these data indicate that Khz-cp preferentially induces apoptosis in cancer cells and that the signaling mechanisms involve an increase in [Ca2+]i, P38 activation, and ROS generation via NADPH oxidase and mitochondria.

Source: BMC Complementary and Alternative Medicine - July 10, 2014 Category: Complementary Medicine Authors: Tae KimJu KimZoo KimRen HuangYoung ChaeRen Wang Source Type: research