Association between oropharyngeal carriage of Kingella kingae and osteoarticular infection in young children: a case-control study.

Association between oropharyngeal carriage of Kingella kingae and osteoarticular infection in young children: a case-control study. CMAJ. 2017 Sep 05;189(35):E1107-E1111 Authors: Gravel J, Ceroni D, Lacroix L, Renaud C, Grimard G, Samara E, Cherkaoui A, Renzi G, Schrenzel J, Manzano S Abstract BACKGROUND: Kingella kingae has been increasingly identified in patients with osteoarticular infections. Our main objective was to evaluate the association between carriage of K. kingae in the oropharynx of preschool children and osteoarticular infections. METHODS: We conducted this prospective case-control study in 2 tertiary care pediatric hospitals (Canada and Switzerland) between 2014 and 2016. Potential cases were children aged 6 to 48 months with a presumptive diagnosis of osteoarticular infection according to the treating emergency physician. Confirmed cases were those with diagnosis of osteomyelitis or septic arthritis proven by positive findings on technetium-labelled bone scan or magnetic resonance imaging or identification of a microorganism in joint aspirate or blood. For each case, we recruited 4 age-matched controls from among children presenting to the same emergency department for trauma. The independent variable was presence of oropharyngeal K. kingae DNA identified by a specific polymerase chain reaction assay. We determined the association between oropharyngeal carriage of K. kingae and definitive osteoarticular infec...
Source: Canadian Medical Association Journal - Category: General Medicine Tags: CMAJ Source Type: research