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Google ’ s Verily is developing AI-powered heart disease test using retinal images

Google (NSDQ:GOOG) parent Alphabet‘s (NSDQ:GOOGL) Verily is developing a new artificial-intelligence powered test that searches for indicators of heart disease risk present in retina images, according to a new study. The study, which has not yet been peer reviewed but has been published by Cornell University, details a new machine-learning powered system designed by Verily to “discover new knowledge from retinal fundus images.” The system operates on data from 284,335 patients, validated on 2 independent datasets of 12,026 and 999 patients, to predict cardiovascular risks “not previously thought to be present or quantifiable in retinal images,” according to the study publication. Researchers claim they were able to use the system to determine a patient’s age accurate to within 3.3 years, gender, smoking status, HbA1c levels, systolic blood pressure and major adverse cardiac events from retinal images. The AI-powered system uses “distinct aspects of the anatomy to generate each prediction,” according to the study, which researchers claim could open up avenues of further research into the technique. Study investigators touted that the system was comparable to the European SCORE risk calculator, but offered the caveat that study came with several limitations, including a “relatively small” dataset size for deep learning. “In particular, although the AUC for cardiovascular events was comparable to SCORE, ...
Source: Mass Device - Category: Medical Devices Authors: Tags: Cardiovascular Imaging Optical/Ophthalmic Research & Development Alphabet Inc. Google Inc. Verily Source Type: news

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This study cohort is a healthy subset of the EpiPath cohort, excluding all participants with acute or chronic diseases. With a mediation analysis we examined whether CMV titers may account for immunosenescence observed in ELA. In this study, we have shown that ELA is associated with higher levels of T cell senescence in healthy participants. Not only did we find a higher number of senescent cells (CD57+), these cells also expressed higher levels of CD57, a cell surface marker for senescence, and were more cytotoxic in ELA compared to controls. Control participants with high CMV titers showed a higher number of senes...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Composite risk scores have been used for decades to identify disease risk and health status in the general population. However, current approaches often fail to identify people who would benefit from intervention or recommend unnecessary intervention. Machine learning promises to improve accuracy, ensuring targeted treatment for patients that need it and reducing unnecessary intervention. Framingham Risk Score, the gold standard for predicting the likelihood of heart disease, predicts hospitalizations with about 56% accuracy. It uses factors such as age, gender, smoking, cholesterol levels, and systolic blood pre...
Source: MDDI - Category: Medical Devices Authors: Tags: R & D Source Type: news
CONCLUSIONS: Perioperative TEE is emerging as a preferred tool to manage hemodynamics in high-risk procedures and in high-risk patients undergoing non-cardiac surgery. A rescue TEE examination protocol is a helpful approach for early identification of the etiology of hemodynamic instability. PMID: 29150779 [PubMed - as supplied by publisher]
Source: Canadian Journal of Anaesthesia - Category: Anesthesiology Authors: Tags: Can J Anaesth Source Type: research
The first hint that something wasn’t quite right with Danny Sanchez-Garcia’s heart came at his mom’s six-month prenatal visit. “There was a little blip on the ultrasound, but then it was gone on the next one, so they didn’t think it was anything and I didn’t worry any more about it,” says Danny’s mom, Cynthia. Cynthia was overjoyed when Danny was born at her local hospital seeming perfectly healthy. But as the hospital staff monitored Danny overnight, they noticed his oxygen level was lower than normal and decided to run more tests. His doctors believed the tests pointed to a...
Source: Thrive, Children's Hospital Boston - Category: Pediatrics Authors: Tags: Diseases & Conditions Our Patients’ Stories Biventricular Repair Complex Biventricular Repair Program congenital heart valve program double outlet right ventricle Dr. Christopher Baird Dr. Roger Breitbart ECMO Pulmonary atresia tetra Source Type: news
Eligibility for heart transplantation in end-stage left heart disease can be affected by the development of pulmonary vasculopathy. This can lead to pulmonary hypertension ([PH]- group-2), which is recognized as a factor of poor prognosis. Literature data regarding pathophysiology and morphology of the pulmonary vascular lesions are scarce in this group of patients.1,2 Additionally, it has been hypothesized that elevation of the pulmonary arterial pressure in the context of left ventricular failure depends on the integrity and functional capacity of the right ventricle.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Just yesterday, the American Heart Association and the American College of Cardiology announced new guideline for hypertension. Below is an excellent summary of this new report. Please discuss the following with your doctor. By Dennis ThompsonHealthDay ReporterMONDAY, Nov. 13, 2017 (HealthDay News) -- Nearly half of all adult Americans will be considered to have high blood pressure under new guidelines issued Monday by the nation's top heart health organizations.The new guidelines lower the diagnostic threshold for stage 1 high blood pressure to 130/80, down from the previous level of 140/90, according to a joint stat...
Source: Dr Portnay - Category: Cardiology Authors: Source Type: blogs
In conclusion, we have developed an effective PILs strategy to deliver the AUF1 plasmid to a specific target, and this system may be useful for the development of new anti-aging drugs. Considering the Evidence for Vascular Amyloidosis as a Cause of Aging https://www.fightaging.org/archives/2017/11/considering-the-evidence-for-vascular-amyloidosis-as-a-cause-of-aging/ The balance of evidence for the aging of the cardiovascular system suggests the following view. It starts off in the blood vessels, with the accumulation of senescent cells and cross-links. Cross-links directly stiffen these tissues, while ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Funding Opportunity PAR-18-091 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement (FOA) is to establish a program of research to advance the understanding, prevention and treatment of pediatric multiple organ dysfunction syndrome (MODS). Given the prevalence and associated morbidity and mortality of MODS in children, the current lack of understanding underscores the need for more basic, exploratory and longitudinal research. Possible topics of study include, but are not limited, to the epidemiology, pathophysiology, monitoring, and treatment of MODS. Studies that assess speci...
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
ConclusionsUp to one‐third of patients with RV scar‐related VT are not classifiable as ARVC/D or CS. These patients had a somewhat better prognosis than ARVC/D or sarcoid and did not develop evidence of these diseases during the initial 2 years of follow‐up. The extent to which this population comprises mild ARVC/D, CS, or other diseases is not clear.
Source: Journal of Cardiovascular Electrophysiology - Category: Cardiology Authors: Tags: ORIGINAL ARTICLE Source Type: research
CONCLUSIONS: The rs12740374 minor allele sequence enhances SORT1 expression in hepatocytes. CRISPR-Cas9 can be used in primary human hepatocytes ex vivo and locus-humanized mice in vivo to interrogate the function of noncoding regulatory regions. induced pluripotent stem cell-derived hepatocyte-like cells experience limitations that prevent faithful modelling of some hepatocyte expression quantitative trait locus. PMID: 29097363 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - Category: Cardiology Authors: Tags: Arterioscler Thromb Vasc Biol Source Type: research
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