Interaction of injectable neurotropic drugs with the red cell membrane.

Interaction of injectable neurotropic drugs with the red cell membrane.
Toxicol In Vitro. 2014 Jul 2;
Authors: Reinhart WH, Lubszky S, Thöny S, Schulzki T
Abstract
The normal red blood cell (RBC) shape is a biconcave discocyte. An intercalation of a drug in the outer half of the membrane lipid bilayer leads to echinocytosis, an intercalation in the inner half to stomatocytosis. We have used the shape transforming capacity of RBCs as a model to analyse the membrane interaction potential of various neurotropic drugs. Chlorpromazine, clomipramine, citalopram, clonazepam, and diazepam induced a reversible stomatocytosis, phenytoin induced echinocytosis, while the anticonvulsants levetirazetam, valproic acid and phenobarbital had no effect. This diversity of RBC shape transformations suggests that the pharmacological action is not linked to the membrane interaction. We conclude that this simple RBC shape transformation assay could be a useful tool to screen for potential drug interactions with cell membranes.
PMID: 24997296 [PubMed - as supplied by publisher]

Source: Toxicology in Vitro - July 2, 2014 Category: Toxicology Authors: Reinhart WH, Lubszky S, Thöny S, Schulzki T Tags: Toxicol In Vitro Source Type: research