CCR6, IL7R, FAS AND MAdCAM-1 Single Nucleotide Polymorphisms are Associated With Higher Incidence of Infections in Allogeneic Stem-Cell Transplant From a Related Donor After a Reduced Intensity Conditioning Regimen: A Multicenter Experience

Infection complications are important cause of morbidity and non-relapse mortality after allogeneic hematopoietic stem cell transplantation (allo-SCT), even in HLA-identical sibling donors. Although there are many studies associating single nucleotide polymorphisms (SNPs) and allo-SCT evolution, these are mainly related with graft versus host disease (GVHD) and/or transplant related mortality (TRM), with few focused on post-allo-SCT infections. This multicentric study analyzes the potential implication of SNPs with cytomegalovirus (CMV) reactivation and fungal infection (FI) development in allo-SCT with reduced intensity conditioning (RIC).

Source: Clinical Lymphoma, Myeloma and Leukemia - September 1, 2017 Category: Hematology Authors: Nerea Arratibel, Maria Garc ía-Alvarez, Oriana Lopez-Godino, Estefania Garcia-Guerrero, Oscar Ferre, Eduardo Rodriguez-Arboli, Albert Esquirol, Cristina Castilla, Rodrigo Martino, Luis Corchete, Inmaculada Heras, Jose Antonio Perez-Simon, Estefanía Pere Source Type: research