Nonalcoholic Fatty Liver Disease Epidemic Increasing Greatly Nonalcoholic Fatty Liver Disease Epidemic Increasing Greatly

The burden of nonalcoholic fatty liver disease (NAFLD) is increasing greatly, and the need for liver transplants is likely to outstrip the supply of donors, researchers report.Reuters Health Information
Source: Medscape Transplantation Headlines - Category: Transplant Surgery Tags: Gastroenterology News Source Type: news

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Authors: Liu K, McCaughan GW Abstract Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world and will soon become the number one cause of hepatocellular carcinoma (HCC), liver transplantation and liver-related mortality. The disease often occurs in the setting of metabolic conditions such as obesity and type II diabetes mellitus. These same metabolic drivers are also risk factors for NAFLD associated HCC which can occur even in the absence of cirrhosis or advanced fibrosis and appears to be phenotypically different to HCCs arising from other chronic liver diseases. The frequ...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Authors: Mandelia C, Kabbany MN, Conjeevaram Selvakumar PK, Alkhouri N Abstract Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the obesity epidemic. Recent studies have clearly shown that the stage of fibrosis in adults with NAFLD is the most important histological feature in long-term outcomes and the development of liver-related complications. Despite the paucity of data regarding the natural history of pediatric NAFLD, its progression to cirrhosis and end-stage liver disease requiring liver transplantation is well documented. Given the high prevalence of NAFLD in children and adults, th...
Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research
Nonalcoholic fatty liver disease (NAFLD) has become a common worldwide condition, the prevalence of which continues to increase with the worldwide surge in the incidence of obesity and diabetes. In the United States alone, NAFLD affects between 60 and 100 million people, including 10% of American children. The spectrum of disease ranges from simple, nonclinically significant hepatic steatosis to steatohepatitis (NASH) to cirrhosis, hepatocellular carcinoma, and decompensated liver disease. In 2016, NAFLD was reported to surpass hepatitis C as the leading indication for liver transplantation among adults under the age of 50...
Source: Clinics in Liver Disease - Category: Gastroenterology Authors: Tags: Preface Source Type: research
Conclusions: With continued high rates of adult obesity and DM, and an aging population, NAFLDā€related liver disease and mortality will increase in the US. Strategies to slow the growth of NAFLD cases and therapeutic options are necessary to mitigate disease burden. This article is protected by copyright. All rights reserved.
Source: Hepatology - Category: Internal Medicine Authors: Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research
Abstract Hepatocellular carcinoma (HCC) is the most frequent primary liver malignancy and the third cause of cancer-related death in the Western Countries. The well-established causes of HCC are chronic liver infections such as hepatitis B virus or chronic hepatitis C virus, nonalcoholic fatty liver disease, consumption of aflatoxins and tobacco smocking. Clinical presentation varies widely; patients can be asymptomatic while symptomatology extends from right upper abdominal quadrant paint and weight loss to obstructive jaundice and lethargy. Imaging is the first key and one of the most important aspects at all st...
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research
Authors: Agustin S, Graupera I, Caballeria J, en nombre del grupo de trabajo sobre «Hígado graso no alcohólico» de la Societat Catalana de Digestologia Abstract Non-alcoholic fatty liver disease (NAFLD) consists of an excessive depositing of fat in the liver, which can end up by causing inflammation, fibrosis and also cirrhosis with the corresponding complications including liver cancer. NAFLD has become the most common liver disease worldwide. The incidence has increased in parallel with the obesity, diabetes and metabolic syndrome epidemic, thus resulting in becoming one of the main indi...
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
Authors: Benedict M, Zhang X Abstract Non-alcoholic fatty liver disease (NAFLD) encompasses the simple steatosis to more progressive steatosis with associated hepatitis, fibrosis, cirrhosis, and in some cases hepatocellular carcinoma. NAFLD is a growing epidemic, not only in the United States, but worldwide in part due to obesity and insulin resistance leading to liver accumulation of triglycerides and free fatty acids. Numerous risk factors for the development of NAFLD have been espoused with most having some form of metabolic derangement or insulin resistance at the core of its pathophysiology. NAFLD patients are...
Source: World Journal of Hepatology - Category: Gastroenterology Tags: World J Hepatol Source Type: research
Authors: Cholankeril G, Patel R, Khurana S, Satapathy SK Abstract With the prevalence of hepatitis C virus expected to decline, the proportion of hepatocellular carcinoma (HCC) related to non-alcoholic steatohepatitis (NASH) is anticipated to increase exponentially due to the growing epidemic of obesity and diabetes. The annual incidence rate of developing HCC in patients with NASH-related cirrhosis is not clearly understood with rates ranging from 2.6%-12.8%. While multiple new mechanisms have been implicated in the development of HCC in NASH; further prospective long-term studies are needed to validate these find...
Source: World Journal of Hepatology - Category: Gastroenterology Tags: World J Hepatol Source Type: research
Hepatocellular carcinoma (HCC) is one of the most common human malignancies and the third leading cause of cancer death worldwide [1]. A retrospective cohort study of indications for adult liver transplantation from 2002 to 2012 revealed a nearly 4-fold increase in patients undergoing liver transplantation for HCC secondary to non-alcoholic steatohepatitis (NASH) compared to only a 2.5-fold increase for HCC secondary to HCV during the study period [2]. With the control of viral hepatitis and the escalating obesity epidemic, nonalcoholic fatty liver disease (NAFLD) associated HCC is occupying a greater proportion of HCC inc...
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research
This article is protected by copyright. All rights reserved.
Source: Hepatology - Category: Internal Medicine Authors: Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research
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