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New Use of Blood Cleaning Device Saves High-Risk Patients With Liver Failure

Severe acute liver failure (ALF), a rare but life-threatening illness, is associated with high death rates if patients don’t receive timely treatment or a liver transplant. Unlike the heart or the kidneys, there is no established mechanical device to replace the liver’s function. Now, University of Maryland School of Medicine (UM SOM) researchers report that a device that removes toxins from the blood can also effectively provide a bridge to liver transplantation or buy time for a traumatically injured liver to heal, suggesting broader uses for the device than previously thought.
Source: University of Maryland School of Medicine News Headlines - Category: Universities & Medical Training Source Type: news

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Authors: Huang S, Tang Y, Zhu Z, Yang J, Zhang Z, Wang L, Sun C, Zhang Y, Zhao Q, Chen M, Wu L, Wang D, Ju W, Guo Z, He X Abstract BACKGROUND The inherent challenges of selecting an acceptable donor for the increasing number and acuity of recipients has forced programs to take increased risks, including accepting donors with a cancer history (DWCH). Outcomes of organ transplantation using organs from DWCH must be clarified. We assessed transplant outcomes of recipients of organs from DWCH. MATERIAL AND METHODS Retrospective analysis of the Scientific Registry of Transplant Recipients data from January 1, 2000 to De...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Short-term outcomes of solid organ transplantation have improved dramatically over the past several decades; however, long-term survival has remained static over the same period, and chronic rejection remains a major cause of graft failure. The importance of donor, or “passenger,” lymphocytes to the induction of tolerance to allografts was recognized in the 1990s, but their precise contribution to graft acceptance or rejection has not been elucidated. Recently, specialized populations of tissue-resident lymphocytes in nonlymphoid organs have been described. These lymphocytes include tissue-resident memory T cel...
Source: Transplantation - Category: Transplant Surgery Tags: Reviews Source Type: research
AbstractPurposeCerebral microbleeds (CMBs) are small rounded lesions representing cerebral hemosiderin deposits surrounded by macrophages that results from previous microhemorrhages. The aim of this study was to review the distribution of cerebral microbleeds in patients with end-stage organ failure and their association with specific end-stage organ failure risk factors.Materials and methodsBetween August 2015 and June 2017, we evaluated 15 patients, 9 males, and 6 females, (mean age 65.5  years). Patients population was subdivided into three groups according to the organ failure: (a) chronic kidney failure (n =...
Source: La Radiologia Medica - Category: Radiology Source Type: research
We report a case of successful combined heart liver transplant in a patient with a congenital solitary kidney. The patient had normal renal function before combined heart-liver transplantation and developed acute kidney injury requiring slow continuous dialysis and subsequent intermittent dialysis for almost 8 weeks post transplantation. Her renal function recovered and she remains off dialysis now 7 months post transplantation. She only currently has mild chronic renal insufficiency. We believe this is the first reported case of successful heart liver transplant in a patient with a congenital solitary kidney.
Source: Transplantation Proceedings - Category: Transplant Surgery Authors: Source Type: research
Making human tissue in a lab has always been more sci-fi than sci-fact, but powerful genetic technologies may change that soon. For the most part, the only way to replace diseased or failing hearts, lungs, kidneys and livers is with donor organs. Even then, many people struggle to find a good biological match with a donor, and 8,000 die each year in the U.S. while waiting for an organ. In one promising solution to the shortage, researchers have been putting a new DNA editing tool called CRISPR through rigorous tests in organ regeneration. Last August, a group of scientists led by George Church, professor of genetics at Har...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime Longevity organ transplants Source Type: news
In conclusion, most experimental data on immune changes with aging show a decline in many immune parameters when compared to young healthy subjects. The bulk of these changes is termed immunosenescence. Immunosenescence has been considered for some time as detrimental because it often leads to subclinical accumulation of pro-inflammatory factors and inflammaging. Together, immunosenescence and inflammaging are suggested to stand at the origin of most of the diseases of the elderly, such as infections, cancer, autoimmune disorders, and chronic inflammatory diseases. However, an increasing number of gerontologists have chall...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Superman, Spiderman, the Flash, the Avengers, Green Arrow, Catwoman. Idolized superheroes are able to fly, jump from one roof to another beating up the bad guys. Although they all have their unique characteristics and superpowers, one thing is common. They all use their abilities to the fullest. Digital health offers you the same. You can become a real superhero if you proactively harness the power of technology for your health. Technology has the potential to transform how we think about our health The current medical system in most countries works as a reactive setting. The patient goes to the doctor with existing sympt...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Cyborgization Future of Medicine Health Sensors & Trackers artificial intelligence comics digital digital health Healthcare Innovation marvel marvel universe superhero superpower technology Source Type: blogs
Hospital officials in Oregon have ended a policy that prevented an undocumented woman from getting a liver transplant because of her immigration status after outcry, according to local news reports. Silvia Lesama-Santos, 46, a mother of four who has lived in the country for at least 30 years, was denied the transplant in a letter Tuesday from […]Related:Robin Williams’s suicide was followed by a sharp rise in ‘copycat’ deathsBillionaire Patrick Soon-Shiong, who just purchased the Los Angeles Times, is a controversial figure in medicineFDA ramps up warnings about kratom, calling unregulate...
Source: Washington Post: To Your Health - Category: Consumer Health News Source Type: news
The incidence of acute kidney injury (AKI) and its impact on chronic kidney disease (CKD) following pediatric nonkidney solid organ transplantation is unknown. We aimed to determine the incidence of AKI and CKD and examine their relationship among children who received a heart, lung, liver, or multiorgan transplant at the Hospital for Sick Children between 2002 and 2011. AKI was assessed in the first year posttransplant. Among 303 children, perioperative AKI (within the first week) occurred in 67% of children, and AKI after the first week occurred in 36%, with the highest incidence among lung and multiorgan recipients. Twe...
Source: American Journal of Transplantation - Category: Transplant Surgery Authors: Tags: ORIGINAL ARTICLE Source Type: research
Abstract SRTR is considering more prominent reporting of program‐specific adjusted transplant rate ratios (TRRs). To enable more useful reporting of TRRs, SRTR updated the transplant rate models to explicitly adjust for components of allocation priority. We evaluated potential associations between TRRs and components of allocation priority that could indicate programs’ ability to manipulate TRRs by denying or delaying access to low‐priority candidates. Despite a strong association with unadjusted TRRs, we found no candidate‐level association between the components of allocation priority and adjusted TRRs. We fo...
Source: American Journal of Transplantation - Category: Transplant Surgery Authors: Tags: Original Article Source Type: research
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