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New Use of Blood Cleaning Device Saves High-Risk Patients With Liver Failure

Severe acute liver failure (ALF), a rare but life-threatening illness, is associated with high death rates if patients don’t receive timely treatment or a liver transplant. Unlike the heart or the kidneys, there is no established mechanical device to replace the liver’s function. Now, University of Maryland School of Medicine (UM SOM) researchers report that a device that removes toxins from the blood can also effectively provide a bridge to liver transplantation or buy time for a traumatically injured liver to heal, suggesting broader uses for the device than previously thought.
Source: University of Maryland School of Medicine News Headlines - Category: Universities & Medical Training Source Type: news

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ABSTRACT Solid organ transplantation is a significant development in the treatment of chronic kidney, liver, heart and lung diseases. This therapeutic approach has increased patient survival and improved quality of life. New surgical techniques and immunosuppressive drugs have been developed to achieve better outcomes. However, the variety of neurological complications following solid organ transplantation is broad and carries prognostic significance. Patients may have involvement of the central or peripheral nervous system due to multiple causes that can vary depending on time of onset after the surgical procedure, the tr...
Source: Arquivos de Neuro-Psiquiatria - Category: Neurology Source Type: research
This study cohort is a healthy subset of the EpiPath cohort, excluding all participants with acute or chronic diseases. With a mediation analysis we examined whether CMV titers may account for immunosenescence observed in ELA. In this study, we have shown that ELA is associated with higher levels of T cell senescence in healthy participants. Not only did we find a higher number of senescent cells (CD57+), these cells also expressed higher levels of CD57, a cell surface marker for senescence, and were more cytotoxic in ELA compared to controls. Control participants with high CMV titers showed a higher number of senes...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Authors: Yeo HJ, Yoon SH, Lee SE, Jeon D, Kim YS, Cho WH, Kim DH Abstract Lung transplantation is the only effective treatment option for patients with end-stage lung disease. However, donor organ shortage makes timely transplant not possible for all patients, especially in Korea. We investigated the number and utilization of donor lungs by retrospectively reviewing all donor organs registered in the Korea Network for Organ Sharing database from March 2012 to March 2016. The donors were stratified into 4 groups by donor acceptability criteria. A total of 1,304 donors were included. Of those, 295 brain-dead donors (...
Source: Journal of Korean Medical Science - Category: Biomedical Science Tags: J Korean Med Sci Source Type: research
Discussion The nail matrix covers the area of the nail plate, and extends proximally in a crescent moon shape with the edges of the crescent extending proximally and inferiorly toward the underlying bone. The nail matrix is a multilayered epithelium that physiologically produces keratinization and gives rise to the nail plate. The distal matrix forms the lower 2/3s of the nail plate and the proximal matrix forms the upper 1/3 of the nail plate. the thickness of the nail plate is proportion to the matrix’s thickness. The nail plate’s free edge contour follows the shape of the nail’s lunula. Melanocytes occ...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Conclusion The clinical features of Japanese patients with systemic AL amyloidosis are similar to those reported previously for cases in the US and Europe. Regarding treatment, a significant number of ASCTs were performed in Japan as well as in Western countries. Surprisingly, a marked number of patients received bortezomib as a treatment for AL amyloidosis. PMID: 29093404 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Danon disease (DD) is an X-linked systemic disorder characterized by left ventricular hypertrophy, mental retardation, and skeletal myopathy.1 DD is caused by a deficiency of the lysosome-associated membrane protein (LAMP-2) which leads to an accumulation of autophagic vacuoles in skeletal and heart muscles, liver, and kidneys (Figure 1A).2 Histological analysis shows disorganized cellular architecture and hypertrophic cardiomyocytes with sarcoplasmic vacuoles. Electrocardiogram usually displays a Wolff-Parkinson-White (WPW) pre-excitation pattern.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Condition:   Physical Activity After Organ Transplantation Intervention:   Other: High-intensity training Sponsor:   Universitaire Ziekenhuizen Leuven Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion: The normal liver has large numbers of CD4 Tregs, CD8+CD28‐ and myeloid‐derived suppressor cells, which are known immunosuppressive cells occurring at much higher levels than those seen in lymph node or peripheral blood. Memory T cells are dramatically increased in rejecting liver allografts of rhesus monkeys compared to those seen in normal RM tissues. This article is protected by copyright. All rights reserved.
Source: Liver Transplantation - Category: Transplant Surgery Authors: Tags: Original Article Source Type: research
The waiting lists for organ transplants are long, and people die daily waiting for transplants that never become available. For those that get a transplant, there is a risk that their immune system could reject it. Using organs from pigs is an alternative to human organs since many are a similar size. However, there is a major risk of rejection, so pig organs aren’t suitable for transplantation into humans in an unmodified state. Miromatrix, a company based in Minnesota, is working hard to find ways to make pig organs more suited to individual human patients. They have developed a “reprogramming” process,...
Source: Medgadget - Category: Medical Devices Authors: Tags: Exclusive Genetics Materials Surgery Source Type: blogs
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