Towards identification and targeting of leukemic stem cells and (EPI)genetically distinct subclones using humanized niche xenograft mouse models

Over the past years it has become clear that multiple genetically distinct subclones can co-exist in patients that suffer from acute myeloid leukemia (AML). These subclones often carry similar founder mutations, but upon leukemic evolution different secondary mutations arise in distinct subclones. Tools to prospectively isolate viable subclones to functionally study them are currently lacking. We performed transcriptome and quantitative proteome analysis on large cohorts of primary AML CD34+ samples and healthy CD34+ controls.
Source: Experimental Hematology - Category: Hematology Authors: Source Type: research