Asymmetries in reciprocal baroreflex mechanisms and chronic pain severity: Focusing on irritable bowel syndrome

Conclusion and InferencesWe anticipate the findings to be a starting point for validating these autonomic metrics of pain suffering and pain coping mechanisms in other chronic pain syndromes to suggest them as biomarkers of its severity and duration for profiling and correct management of chronic pain patients. Spontaneous cardiac baroreflex responses were obtained by continuous recordings of systolic blood pressure and electrocardiogram in groups of control subjects and patients with irritable bowel syndrome (IBS) during resting baseline recording. Severity of abdominal pain in patients with IBS determines an asymmetrical reciprocity in baroreflex responses to falls and rises of systolic blood pressure that indicates pain resilience, pain decompensation, pain adaptation, and pain aggravation mechanisms related to the disease duration. These findings could help to improve and personalize treatment of the IBS.
Source: Neurogastroenterology and Motility - Category: Gastroenterology Authors: Tags: ORIGINAL ARTICLE Source Type: research