AWAKE-HF: Rationale and Design of a Study Using a Wearable Biosensor to Objectively Evaluate the Effect of Sacubitril/Valsartan Initiation on Measures of Physical Activity, Symptoms, and Sleep, as Health-Related Quality of Life Functions in Subjects with Heart Failure

This study explores early changes in objective HRQoL measures (physical activity, sleep) in HFrEF subjects initiating S/V versus enalapril. Methods: AWAKE-HF is a prospective, multicenter, double-blind, randomized trial assessing physical activity during waking and sleeping hours, subjective sleep quality, and HRQoL of approximately 140 HFrEF subjects (LVEF ≤40%, NYHA functional class II-III) in their unrestricted home environment.

Source: Journal of Cardiac Failure - August 1, 2017 Category: Cardiology Authors: Raj M. Khandwalla, Kade T. Birkeland, James Thomas Heywood, Robert L. Owens, Steven R. Steinhubl, Daniel Grant, Kevin McCague, Emmanuel Fombu, Jerome B. Riebman Source Type: research