Hepatoprotective and cytotoxic activities of Anvillea garcinii and isolation of four new secondary metabolites

AbstractAnvillea garcinii is a medicinal plant traditionally used for the treatment of dysentery, gastrointestinal troubles, hepatitis, lung disease, colds, digestive problems and pulmonary affections and in liver diseases. Four new sesquiterpene lactones, garcinamines A –D, along with seven known compounds, were isolated from the leaves ofA. garcinii. This is the first report of the isolation of amino acid analogues of parthenolide-type sesquiterpene lactones from the family Asteraceae. Total ethanol extract of leaves as well as the chloroform andn-butanol fractions were tested for their hepatoprotective effect using the carbon tetrachloride liver toxicity model. The chloroform fraction, at a dose of 400  mg/kg, demonstrated a significant hepatoprotective effect comparable to silymarin in all serum and tissue parameters. The cytotoxicity of all extracts and compounds were evaluated against five human cancer cell lines: MCF-7, HCT-116, HepG2, Hela and A-549. The results indicated that the chloroform andn-butanol fractions and compounds3,4,7 and8 displayed significant cytotoxic activity against these cell lines.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research