Cancers, Vol. 9, Pages 101: Epithelial-to-Mesenchymal Transition and MicroRNAs in Lung Cancer
Cancers, Vol. 9, Pages 101: Epithelial-to-Mesenchymal Transition and MicroRNAs in Lung Cancer
Cancers doi: 10.3390/cancers9080101
Authors:
Antoine Legras
Nicolas Pécuchet
Sandrine Imbeaud
Karine Pallier
Audrey Didelot
Hélène Roussel
Laure Gibault
Elizabeth Fabre
Françoise Le Pimpec-Barthes
Pierre Laurent-Puig
Hélène Blons
Despite major advances, non-small cell lung cancer (NSCLC) remains the major cause of cancer-related death in developed countries. Metastasis and drug resistance are the main factors contributing to relapse and death. Epithelial-to-mesenchymal transition (EMT) is a complex molecular and cellular process involved in tissue remodelling that was extensively studied as an actor of tumour progression, metastasis and drug resistance in many cancer types and in lung cancers. Here we described with an emphasis on NSCLC how the changes in signalling pathways, transcription factors expression or microRNAs that occur in cancer promote EMT. Understanding the biology of EMT will help to define reversing process and treatment strategies. We will see that this complex mechanism is related to inflammation, cell mobility and stem cell features and that it is a dynamic process. The existence of intermediate phenotypes and tumour heterogeneity may be debated in the literature concerning EMT markers, EMT signatures and clinical consequences in NSCLC. However, given the role of EMT in metastasis and in drug resistance the development of EMT inhi...
Source: Cancers - Category: Cancer & Oncology Authors: Antoine Legras Nicolas P écuchet Sandrine Imbeaud Karine Pallier Audrey Didelot H élène Roussel Laure Gibault Elizabeth Fabre Fran çoise Le Pimpec-Barthes Pierre Laurent-Puig H élène Blons Tags: Review Source Type: research
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