Neonatal fluoxetine exposure modulates serotonergic neurotransmission and disturb inhibitory action of serotonin on food intake.

Neonatal fluoxetine exposure modulates serotonergic neurotransmission and disturb inhibitory action of serotonin on food intake.
Behav Brain Res. 2017 Jul 26;:
Authors: Pinheiro IL, da Silva AI, Reginato A, da Silva Filho RC, Galindo LCM, Matos RJB, de Souza Ferraz Junior JC, Toscano Meneses da Silva AE, Milanski Ferreira M, Manhães de Castro R, de Souza SL
Abstract
The neurotransmitter serotonin (5-HT) acts as an important regulator of the critical neurodevelopmental processes and thus alterations in 5-HT signaling early promotes permanent structural and functional changes in brain. The selective serotonin reuptake inhibitors (SSRIs), as fluoxetine and citalopram, blocking serotonin transporter (SERT) at the presynaptic neuron, which regulates extracellular 5-HT levels. Evidence suggests that the exposure to SSRIs in the neurodevelopmental period may alters 5-HT signaling sensitivity on food intake control. The aim of the present study was to evaluate the effects of neonatal exposure to fluoxetine on molecular and cellular components of the serotonergic system and food intake control in young animals.
METHODS: The animals were divided according to experimental manipulation, Fluoxetine Group (FG): male pups received application of fluoxetine (10mg/kg, 10μL/g) and Saline Group (SG): male pups received saline application (0.9% NaCl, 10μL/g), both throughout lactation (PND1 to PND21). They evaluated body weight, food intake, ...

Source: Behavioural Brain Research - July 26, 2017 Category: Neurology Authors: Pinheiro IL, da Silva AI, Reginato A, da Silva Filho RC, Galindo LCM, Matos RJB, de Souza Ferraz Junior JC, Toscano Meneses da Silva AE, Milanski Ferreira M, Manhães de Castro R, de Souza SL Tags: Behav Brain Res Source Type: research