The c.1085A > G genetic variant of CSF1R gene regulates tumor immunity by altering the proliferation, polarization, and function of macrophages.

Conclusions: </p> <p>The CSF1R c.1085A>G genetic variant regulates tumor immunity by altering the polarization and function of macrophages. This genetic variant confers the sensitivity to CSF-1R inhibitors, implying as a biomarker in targeting CSF-1R signaling for cancer treatment.
PMID: 28724665 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - July 19, 2017 Category: Cancer & Oncology Authors: Yeh YM, Hsu SJ, Lin PC, Hsu KF, Wu PY, Su WC, Chang JY, Shen MR Tags: Clin Cancer Res Source Type: research