Epidemiological Cut-off Value of Clinical Isolates of Burkholderia pseudomallei from Northern Queensland to Meropenem, Ceftazidime, Trimethoprim-Sulphamethoxazole, and Doxycycline by Microbroth Dilution

In this study, we assess using broth microdilution the MIC of meropenem, ceftazidime, TMP-SMX and doxycycline for a library of 234 well characterised clinical isolates of B. pseudomallei from northern Queensland, Australia. The resultant histograms and aggregate data represent the first MIC profile of a large library of B. pseudomallei that has been successfully produced using microbroth dilution. The MIC profiles can be used to contribute towards a determination of an ECOFF for this species for these agents, which will aid in the setting and refining of clinical breakpoints for the most important antimicrobials used to treat melioidosis.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research