Patients with ALS show highly correlated progression rates in left and right limb muscles

Conclusions:
First, this study demonstrates a high degree of power when using unilateral treatment approaches to detect a slowing in disease progression in smaller groups of patients, thus allowing for paired statistical tests. These findings will be useful in transplantation trials that use muscle decline to track disease progression in ALS. Second, these findings discuss methods, such as tactical selection of muscle groups, which can improve the power efficiency of all ALS clinical trials.

Source: Neurology - July 10, 2017 Category: Neurology Authors: Rushton, D. J., Andres, P. L., Allred, P., Baloh, R. H., Svendsen, C. N. Tags: All Clinical Neurology, Amyotrophic lateral sclerosis ARTICLE Source Type: research