CSF sAPP{beta}, YKL-40, and neurofilament light in frontotemporal lobar degeneration

Conclusions:
The combination of sAPPβ with YKL-40 and with NfL in CSF could be useful to increase the certainty of the diagnosis of FTLD-related syndromes in clinical practice.

Classification of evidence:
This study provides Class III evidence that CSF levels of sAPPβ, YKL-40, and NfL are useful to identify patients with FTLD-related syndromes.

Source: Neurology - July 10, 2017 Category: Neurology Authors: Alcolea, D., Vilaplana, E., Suarez-Calvet, M., Illan-Gala, I., Blesa, R., Clarimon, J., Llado, A., Sanchez-Valle, R., Molinuevo, J. L., Garcia-Ribas, G., Compta, Y., Marti, M. J., Pinol-Ripoll, G., Amer-Ferrer, G., Noguera, A., Garcia-Martin, A., Fortea, Tags: MRI, Frontotemporal dementia, Cerebrospinal Fluid, Cognitive aging, Assessment of cognitive disorders/dementia ARTICLE Source Type: research