Simultaneous quantitation of meperidine, nor-meperidine, tramadol, propoxyphene and nor-propoxyphene, in human plasma using solid-phase extraction and gas chromatography-mass spectrometry: Method validation and application to cardiovascular safety of therapeutic doses.

CONCLUSIONS: A GC/MS method for the rapid and simultaneous determination of meperidine, normeperidine, tramadol, propoxyphene and norpropoxyphene in human plasma was developed, optimized and validated. This procedure was shown to be sensitive and specific using small specimen amounts, suitable for application in routine analysis for forensic purposes and therapeutic monitoring. To our knowledge, this is the first full validation of the simultaneous determination of these opioids and their metabolites in plasma samples.
PMID: 28686794 [PubMed - as supplied by publisher]

Source: Rapid Communications in Mass Spectrometry : RCM - July 7, 2017 Category: Chemistry Authors: Fernández N, Olivera NM, Keller GA, Diez RA, Di Girolamo G, Quiroga PN Tags: Rapid Commun Mass Spectrom Source Type: research