Genomic characterization of travel-associated dengue viruses isolated at entry-exit ports in Fujian province, China, 2013-2015.

In this study, a total of three DENV-2 and two DENV-4 strains were isolated from suspected febrile travelers at two ports-of-entry in Fujian during 2013-2015. Complete viral genome sequences of these new isolates were obtained with Sanger chemistry. Genomic sequence analysis revealed that these strains belonged to genotypes of 2-Cosmopolitan and 4-II. In consistence with the patients' travel information, phylogenetic analyses of complete coding regions also indicated that most of the new isolates were genetically close to the circulating strains in Southeast Asia, rather than previous Chinese strains available. Therefore, phylogenetic analyses of the imported DENV demonstrated that multiple introductions of DENV emerged continuously in Fujian, and highlighted the importance of dengue surveillance at entry-exit ports in the subtropical regions of south China. PMID: 28674315 [PubMed - as supplied by publisher]
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research