Synthesis, X-ray structure of organometallic ruthenium (II) p-cymene complexes based on P- and N- donor ligands and their in  vitro antibacterial and anticancer studies

Publication date: 1 October 2017 Source:Journal of Organometallic Chemistry, Volume 846 Author(s): Parichad Chuklin, Vachirawit Chalermpanaphan, Tidarat Nhukeaw, Saowanit Saithong, Kittipong Chainok, Sauwalak Phongpaichit, Adisorn Ratanaphan, Nararak Leesakul Two new arene compounds containing bis-diphosphinomethane (dppm) and tert-butylpyridine (tbp) ligands as important components in ruthenium(II) complexes were synthesized and characterized by X-ray crystallography, and spectroscopy of 1H NMR, 13C NMR, 2D-NMR, FTIR and CHN analysis. The synthesized complexes were evaluated in vitro as anticancer agents of human breast cancer cell lines, MCF-7 and HCC1937, using the MTT assay. Both complexes showed an interesting behavior especially the compound of [Ru(p-cymene) (dppm)Cl2]. It exhibited anticancer activity against both tested cell lines with greater IC50 values than cisplatin against all breast cancer cells. Both MCF-7 and HCC1937 cells exhibited 16-fold sensitivity to the [Ru(p-cymene)(dppm)Cl2] compared to cisplatin. Furthermore, the [Ru(p-cymene)(dppm)Cl2] complex significantly inhibited both Staphylococcus aureus ATCC25923 and MRSA = methicillin resistant Staphylococcus aureus with MIC/MBC values of 8/200 μg mL−1 and 32/128 μg mL−1, respectively. In addition, it showed inhibition activity on Cryptococcus neoformans ATCC90113 flucytosine - resistant, CN90113, with an MIC/MBC value of 64/128 μg mL−1. Graphical abstract
Source: Journal of Organometallic Chemistry - Category: Chemistry Source Type: research