Impact of polymorphism rs7041 and rs4588 of Vitamin D Binding Protein on the extent of coronary artery disease

25-hydroxyvitamin D deficiency represents a widespread social problem but also an emerging risk factor for cardiovascular disease. Genetic variants of the Vitamin D Binding Protein (VDBP), the main transporter of vitamin D in the bloodstream, have been shown to account for a significant variability in the levels and systemic effects of vitamin D. We investigated whether the single nucleotide polymorphisms, rs7041 and rs4588, of VDBP are associated to the prevalence and extent of coronary artery disease.

Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - June 24, 2017 Category: Nutrition Authors: Veronica Daffara, Monica Verdoia, Roberta Rolla, Matteo Nardin, Paolo Marino, Giorgio Bellomo, Alessandro Carriero, Giuseppe De Luca, the Novara Atherosclerosis Study Group (NAS) Source Type: research