Early sensitization of myofilaments to Ca 2+ prevents genetically linked dilated cardiomyopathy in mice

ConclusionOur data indicate that decreased myofilament Ca2+ sensitivity is an essential element in the pathophysiology of thin filament linked DCM. Sensitization of myofilaments to Ca2+ in the early stage of DCM may be a useful therapeutic strategy in thin filament linked DCM.
Source: Cardiovascular Research - Category: Cardiology Source Type: research