Transthyretin stability is critical in assisting beta amyloid clearance- Relevance of transthyretin stabilization in Alzheimer's disease.

CONCLUSION: TTR stabilization exerts a positive effect on Aβ clearance and LRP1 levels, suggesting that TTR protective role in AD is dependent on its stability. These results provide relevant information for the design of TTR-based therapeutic strategies for AD.
PMID: 28570028 [PubMed - as supplied by publisher]

Source: CNS Neuroscience and Therapeutics - June 1, 2017 Category: Neuroscience Authors: Alemi M, Silva SC, Santana I, Cardoso I Tags: CNS Neurosci Ther Source Type: research