Cerebral compensation during motor function in Friedreich ataxia: The IMAGE ‐FRDA study

Discussion: Compensatory activity is evident in the cerebral cortex in individuals with Friedreich ataxia. Early compensation followed by later decline in premotor/ventral attention systems demonstrates capacity‐limited neural reserve, while the additional engagement of higher order brain networks is indicative of compensatory task strategies. Network‐level changes in cerebral brain function thus potentially serve to mitigate the impact of motor impairments in Friedreich ataxia. © 2017 International Parkinson and Movement Disorder Society

Source: Movement Disorders - May 1, 2017 Category: Neurology Authors: Ian H. Harding, Louise A. Corben, Martin B. Delatycki, Monique R. Stagnitti, Elsdon Storey, Gary F. Egan, Nellie Georgiou ‐Karistianis Tags: Research Article Source Type: research