Clinical, radiographic and biochemical characteristics of adult hypophosphatasia

ConclusionAdult HPP presents with a wide range of clinical symptoms and is not associated with low bone mass in general. PLP seems to be a good marker for disease severity in adult patients as its level is correlated with the occurrence of fractures and number of symptoms.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research

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Abstract Purinergic signaling was proposed in 1972, after it was demonstrated that adenosine 5'-triphosphate (ATP) was a transmitter in nonadrenergic, noncholinergic inhibitory nerves supplying the guinea-pig taenia coli. Later, ATP was identified as an excitatory cotransmitter in sympathetic and parasympathetic nerves, and it is now apparent that ATP acts as a cotransmitter in most, if not all, nerves in both the peripheral nervous system and central nervous system (CNS). ATP acts as a short-term signaling molecule in neurotransmission, neuromodulation, and neurosecretion. It also has potent, long-term (trophic) ...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
Osteoporosis is a condition in which bones become porous (less dense) and weaker. It affects 10 million people in the United States: approximately eight million women and two million men. As bone weakens, people are more likely to experience fractures, especially in the spine, hip, and forearm. This causes pain, diminishes a person’s ability to function, and reduces quality of life. Anything that can lower the risk of osteoporosis and fractures has major positive public health implications. That’s why a new drug called romosozumab is getting a lot of attention. Which medications can help treat osteoporosis? The...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Bones and joints Menopause Osteoporosis Women's Health Source Type: blogs
AbstractObjectiveOsteoporosis is a skeletal disease with decreased bone mass and alteration in microarchitecture of bone tissue, and these changes put patients in risk of bone fracture. As a common symptom of osteoporosis and complication of osteoporotic fracture, chronic pain is a headache for clinicians. Nonsteroidal anti ‐inflammatory drugs (NSAIDs), selective COX‐2 inhibitors and opioid drugs can temporarily reduce osteoporotic pain but have relevant side effects, such as addiction, tolerability and safety. The review summarized the recent advancements in the study of CB receptors in osteoporosis and osteoporot ic ...
Source: Journal of Pharmacy and Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Review Source Type: research
The very large economic and social burdens of fracture-related complications make rapid fracture healing a major public health goal. The role of parathyroid hormone (PTH) in treating osteoporosis is generally accepted, but the effect of PTH on fracture healing is controversial. This meta-analysis was designed to investigate the efficacy and safety of PTH in fracture healing. The EMBASE, PubMed, and Cochrane Library databases were systematically searched from the inception dates to April 26, 2018. The primary randomized clinical trials comparing PTH treatment for fracture healing with placebo or no treatment were identified...
Source: Clinics - Category: General Medicine Source Type: research
The very large economic and social burdens of fracture-related complications make rapid fracture healing a major public health goal. The role of parathyroid hormone (PTH) in treating osteoporosis is generally accepted, but the effect of PTH on fracture healing is controversial. This meta-analysis was designed to investigate the efficacy and safety of PTH in fracture healing. The EMBASE, PubMed, and Cochrane Library databases were systematically searched from the inception dates to April 26, 2018. The primary randomized clinical trials comparing PTH treatment for fracture healing with placebo or no treatment were identified...
Source: Clinics - Category: General Medicine Source Type: research
Ryan R. Kelly1,2†, Lindsay T. McDonald1,2†, Nathaniel R. Jensen1,2, Sara J. Sidles1,2 and Amanda C. LaRue1,2* 1Research Services, Ralph H. Johnson VA Medical Center, Charleston, SC, United States 2Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States The significant biochemical and physiological effects of psychological stress are beginning to be recognized as exacerbating common diseases, including osteoporosis. This review discusses the current evidence for psychological stress-associated mental health disorders as risk factors for os...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Medication side-effects can seem unbearable at times: dry mouth, nausea, dizziness, constipation. Certain prescriptions can also increase our risks for developing chronic conditions like thyroid disease and diabetes. Three years ago, I decided that the pills’ side-effects weren’t worth the relief they brought, so I slowly weaned off all my medication. I then plummeted into a severe depression that ended up taking a far greater toll on my health than the nuisance of my drugs. You may be justifiably concerned about how your mood stabilizer and antidepressant are altering your biochemistry, but also consider the g...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Depression General Medications Antidepressant Cognitive Decline Diabetes Mood Stabilizer Source Type: blogs
Conditions:   Organic, Including Symptomatic, Mental Disorders;   Substance Use;   Schizophrenia;   Mood [Affective] Disorders;   Neurotic, Stress-related and Somatoform Disorders;   Eating Disorder;   Disorders of Adult Personality and Behavior;   Mental Retardation;   Disorder of  Psychological Development;   Behavioural Disorder;   Hypertension;   Dyslipidemias;   Ischemic Heart Disease;   Atrial Fibrillation;   Heart ...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS: Bone marrow aspirates from patients with SM had activated mast cells and eosinophils that displayed robust expression of Siglec-8. AK002 demonstrated SM mast cell inhibition in ex vivo bone marrow aspirates. AK002 also had depleting effects on eosinophils, which may be valuable to SM patients with associated eosinophilia. These encouraging results could represent a novel approach for the treatment of SM.DisclosuresYoungblood: Allakos, Inc.: Employment. Brock: Allakos, Inc.: Employment. Leung: Allakos, Inc.: Employment. Chang: Allakos, Inc.: Employment. Bebbington: Allakos, Inc.: Employment. Tomasevic: Allakos, Inc.: Employment.
Source: Blood - Category: Hematology Authors: Tags: 201. Granulocytes, Monocytes, and Macrophages: Poster I Source Type: research
You're reading 10 Ways Chronic Stress Is Killing Your Quality Of Life, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. Stress is something which is almost unavoidable in modern life. While the right amount of stress motivates individual performance, it is necessary if you could distinguish whether your stress is good or chronic. Chronic stress derives from repeated interaction of the body to intense and stressful situations, contributing to the release of stress hormone. The stress is troublesome when it comes to chronic,...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: depression featured self improvement anxiety bad habits chronic stress Source Type: blogs
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