The immunology of atherosclerosis
Nature Reviews Nephrology 13, 368 (2017). doi:10.1038/nrneph.2017.51 Authors: Anton Gisterå &Göran K. Hansson Cardiovascular disease is the leading cause of death worldwide, both in the general population and among patients with chronic kidney disease (CKD). In most cases, the underlying cause of the cardiovascular event is atherosclerosis — a chronic inflammatory disease. CKD accelerates atherosclerosis via augmentation of
Authors: Ohashi N, Aoki T, Matsuyama T, Ishigaki S, Isobe S, Katahashi N, Sato T, Fujikura T, Kato A, Yasuda H Abstract Objective Urinary angiotensinogen (AGT) is a surrogate marker for intrarenal renin-angiotensin system (RAS) activity that plays an important role in the development of renal damage. Urinary AGT levels are determined by the filtration of plasma AGT through the damaged glomeruli and production of AGT in the proximal tubules. However, the relative merits of the filtration and production of urinary AGT levels in chronic kidney diseases (CKD) have not been clarified. Therefore, we investigated them in ...
Publication date: Available online 20 September 2019Source: Redox BiologyAuthor(s): Mercedes Muñoz, Maria Elvira López-Oliva, Claudia Rodríguez, María Pilar Martínez, Javier Sáenz-Medina, Ana Sánchez, Belén Climent, Sara Benedito, Albino García-Sacristán, Luis Rivera, Medardo Hernández, Dolores PrietoAbstractOxidative stress-associated endothelial dysfunction is a key pathogenic factor underlying the microvascular complications of metabolic disease. NADPH oxidase (Nox) is a major source of oxidative stress in diabetic nephropathy and chronic kidne...
Authors: Rossi M, Delbauve S, Roumeguère T, Wespes E, Leo O, Flamand V, Le Moine A, Hougardy JM Abstract Ischemia-reperfusion injury (IRI) is a leading cause of acute kidney injury (AKI), which contributes to the development of chronic kidney disease (CKD). IRI-induced AKI releases proinflammatory cytokines (e.g. IL-1β, TNF-α, IL-6) that induce a systemic inflammatory response, resulting in proinflammatory cells recruitment and remote organ damage. AKI is associated with poor outcomes, particularly when extrarenal complications or distant organ injuries occur. Acute lung injury (ALI) is a major re...
Guideline-changing trial results released earlier in 2019 suggest that SGLT2 inhibitors could be a viable treatment solution for patients with diabetes and evidence of kidney damage.
Conclusion: Cases of chronic kidney disease mineral and bone disorder with pronounced clinical sequelae occur uncommonly in contemporary practice because of early detection and effective therapies. To our knowledge, this report is the first case in the literature of severe thoracic involvement manifesting as respiratory failure. PMID: 31528143 [PubMed]
ConclusionThe dipstick urinalysis for proteinuria appears less reliable than expected, suggesting that the quantitative measurement of urine protein should be performed even during mass health checkups to ensure the early detection and prevention of CKD.
Conclusion: The severity of the comorbidity burden associated with premature ageing in adults with ASD and ID highlight their crucial need of personalized medical care.
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High serum concentrations of the phosphaturic hormone, fibroblast growth factor 23 (FGF23), contribute to various tissue injuries. In chronic kidney disease, the sources of FGF23 and the stimuli that control FGF23 production differ from those in the physiologic scenario. Mediators of inflammation are intensively studied as potential factors that contribute to FGF23 elevations and thereby might function as drug targets to lower FGF23 levels. The present study focuses on tumor necrosis factor.
Bardoxolone methyl has been considered a potential therapy for several types of kidney disease because it activates a cytoprotective factor and inhibits a proinflammatory factor. In the Bardoxolone Methyl Evaluation in Patients With Chronic Kidney Disease and Type 2 Diabetes (BEACON) trial, bardoxolone was tested in patients with diabetic nephropathy and advanced chronic kidney disease (CKD) and was found to improve estimated glomerular filtration rate (eGFR); however, it also increased albuminuria.