Expression of PD-L1 in keratoacanthoma and different stages of progression in cutaneous squamous cell carcinoma

ConclusionsPD-L1 is differently expressed in cSCC and closely related non-melanoma skin cancer. cSCC exhibit PD-L1 expression in a fourth of cases, indicating that PD1/PD-L1 inhibitors might be beneficial in a proportion of patients with an inoperable or metastatic cSCC. Unlike AK and BD, TILs and tumour cells of KA and cSCC present very similar PD-L1 expression profiles indicating a common immune escape mechanism.
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research