Paraquat poisoning: Acute lung injury - a missed diagnosis.
We report the case of a 28-year-old man admitted to the casualty department at Ngwelezana Hospital, Empangeni, KwaZulu-Natal, South Africa, with a history of vomiting and abdominal pain after ingestion of ~100 mL of an unknown substance, later identified as paraquat, together with an unknown amount of alcohol, in a suicide attempt. He developed respiratory distress associated with lung parenchymal infiltrates that required ventilatory support and later a spontaneous pneumothorax, and died in the intensive care unit. We discuss the importance of a high index of suspicion of paraquat poisoning in rural areas, where paraquat is readily available as a herbicide on farms, in patients with a similar presentation. We further stress the importance of identifying the classic radiological progression after paraquat poisoning, to help avoid a delay in diagnosis if the culprit substance is not known (as happened in our case). Lastly, we look at the importance of avoiding oxygen supplementation, and early administration of immunosuppressive therapy, to improve outcome. PMID: 28492119 [PubMed - in process]
In this study, we used qPCR to quantify mtDNA copy number in 15 Holocaust survivors and 102 of their second- and third-generation descendants from the Czech Republic, many of whom suffer from PTSD, and compared them to controls in the respective generations. We found no significant difference in mtDNA copy number in the Holocaust survivors compared to controls, whether they have PTSD or not, and no significant elevation in descendants of female Holocaust survivors as compared to descendants of male survivors or controls. Our results showed no evidence of persistence or inheritance of mtDNA changes in Holocaust survivors, t...
Conclusion: Serum GGT level was a significant predictor of subsequent risk of diabetes mellitus, which increased by 4% for every 1 IU/L increase in GGT when GGT was less than 24 IU/L. PMID: 32215009 [PubMed]
Publication date: Available online 27 March 2020Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Feiyan Liu, Yu Liu, Xizhuo Sun, Zhaoxia Yin, Honghui Li, Kunpeng Deng, Yang Zhao, Bingyuan Wang, Yongcheng Ren, Xuejiao Liu, Dongdong Zhang, Xu Chen, Cheng Cheng, Leilei Liu, Dechen Liu, Guozhen Chen, Shihao Hong, Chongjian Wang, Ming Zhang, Dongsheng Hu
Publication date: Available online 27 March 2020Source: Brain, Behavior, and ImmunityAuthor(s): Richard T. Liu, Aislinn D. Rowan-Nash, Ana E. Sheehan, Rachel F.L. Walsh, Christina M. Sanzari, Benjamin J. Korry, Peter Belenky
Publication date: Available online 27 March 2020Source: Brain, Behavior, and ImmunityAuthor(s): Mpumelelo Ntogwa, Satoshi Imai, Ren Hiraiwa, Madoka Koyanagi, Mayuna Matsumoto, Takashi Ogihara, Shunsaku Nakagawa, Tomohiro Omura, Atsushi Yonezawa, Takayuki Nakagawa, Kazuo Matsubara
Publication date: Available online 27 March 2020Source: Brain StimulationAuthor(s): Maxim Zavorotnyy, Rebecca Zoellner, Henning Rekate, Patricia Dietsche, Miriam Bopp, Jens Sommer, Tina Meller, Axel Krug, Igor Nenadić
Publication date: Available online 27 March 2020Source: Journal of Hospital InfectionAuthor(s): H.J. Breidablik, D.E. Lysebo, L. Johannesse, Å. Skare, O. Kleiven, J.R. Andersen
The objective was to analyze the association between psychosocial risk factors, organizational dimensions, workplace violence, and indicators of mental health problems in three Chilean hospitals. A total of 1,023 workers answered a questionnaire, and descriptive, bivariate (chi-square), and multivariate (logistic regression with odds ratio as the measure of association) analyses were performed. Of all the interviewees, 14.7% reported workplace violence. Increased odds of workplace violence were associated with exposure to ISOSTRAIN (OR = 2.32, p = 0.001), effort-reward imbalance (OR = 5.52, p ≤ 0.001), tyrannical leader...
The objective was to investigate sleep disorders and associated sociodemographic and behavioral factors. A census of university students was carried out. Questions extracted from the Munich Chronotype Questionnaire investigated: insufficient sleep duration (
Publication date: Available online 27 March 2020Source: Anaesthesia Critical Care &Pain MedicineAuthor(s): A. Roquilly, B. Vigué, M. Boutonnet, P. Bouzat, K. Buffenoir, E. Cesareo, A. Chauvin, C. Court, F. Cook, A.C. de Crouy, P. Denys, J. Duranteau, S. Fuentes, T. Gauss, T. Geeraerts, C. Laplace, V. Martinez, J.F. Payen, B. Perrouin-Verbe, A. Rodrigues