Early cortical metabolic rearrangement related to clinical data in idiopathic sudden sensorineural hearing loss.

Early cortical metabolic rearrangement related to clinical data in idiopathic sudden sensorineural hearing loss. Hear Res. 2017 Apr 25;350:91-99 Authors: Micarelli A, Chiaravalloti A, Viziano A, Danieli R, Schillaci O, Alessandrini M Abstract Results in studies concerning cortical changes in idiopathic sudden sensorineural hearing loss (ISSNHL) are not homogeneous, in particular due to the different neuroimaging techniques implemented and the diverse stages of ISSNHL studied. Considering the recent advances in state-of-the-art positron emission tomography (PET) cameras, the aim of this study was to gain more insight into the neuroanatomical differences associated with the earliest stages of unilateral ISSNHL and clinical-perceptual performance changes. After an audiological examination including the mean auditory threshold (mean AT), mean speech discrimination score (mean SDS) and Tinnitus Handicap Inventory (THI), 14 right-handed ISSNHL patients underwent brain [(18)F]fluorodeoxyglucose (FDG)-PET within 72 h of the onset of symptoms. When compared to an homogeneous group of 35 healthy subjects by means of statistical parametric mapping, a relative increase in FDG uptake was found in the right superior and medial frontal gyrus as well as in the right anterior cingulate cortex in ISSNHL patients. Conversely, the same group showed a significant relative decrease in FDG uptake in the right middle temporal, precentral and postcentral gy...
Source: Hearing Research - Category: Audiology Authors: Tags: Hear Res Source Type: research