Glucose-regulated protein 78 (GRP78) in plasma and CSF is associated with Parkinsons disease. (S39.008)

Conclusions:Our pilot study suggests that UPR is likely compromised in PD and can be measured in plasma and CSF. With further study, GRP78 may have value as a potential PD biomarker.Study Supported by:This study was made possible by the Clinical and Translational Science Collaborative of Cleveland, UL1TR000439 from the National Center for Advancing Translational Sciences (NCATS) component of the National Institutes of Health and NIH roadmap for Medical Research. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH.The BioFIND study was sponsored by the Michael J. Fox Foundation (MJFF) for Parkinson’s Research with support from the National Institute of Neurological Disorders and Stroke (NINDS). We thank MJFF, Dr. Katherine Kopil (Senior Associate Director, Research Programs, MJFF), Dr. Yiyuan Yuan and Mr. Lucas Hoffman for their support.Disclosure: Dr. Gupta has nothing to disclose. Dr. Hoppel has nothing to disclose. Dr. Goldman has received personal compensation for activities with Acadia, Biogen, Teva, Pfizer, Pri-Med, MedEdicus as a consultant, advisory board member, and for educational activities. Dr. Goldman has received research support from NIH, Michael J. Fox Foundation, Rush University Medical Center, Parkinson’s Disease Foundation, National Parkinson Foundation, Consolidated Anti-Aging, Acadia, Teva, and Biotie. Dr. Minkler has nothing to disclose. Dr. Liu has nothing to disclose. Dr. K...
Source: Neurology - Category: Neurology Authors: Tags: Movement Disorders: Functional and Structural Imaging in Parkinson ' s Disease Source Type: research