4-year-old boy with acute ischemic stroke treated with intravenous tissue plasminogen activase. (P1.285)

Conclusions:The TIPS trial is underway, which utilizes a classic safety dose finding method to select a safe dose of IV tPA. The child in our case was successfully treated with a dose of 0.75 mg/kg of IV tPA. It has been suggested the appropriate dose may actually be higher than the standard used in adults due to the developmental trajectory of the fibrinolytic system during childhood, as children have lower endogenous tPA and higher plasminogen activator inhibitor-1 levels.Disclosure: Dr. Derani has nothing to disclose. Dr. Kassab has nothing to disclose.
Source: Neurology - Category: Neurology Authors: Tags: Cerebrovascular Disease Case Reports I Source Type: research