Neuropathic pain as the presenting symptom of adult-onset Alexanders Disease (P1.154)

Conclusions:Alexander’s disease is a rare leukodystrophy with both AD and sporadic pattern of inheritance. It is caused by a loss of function mutation in the alpha isoform of glial fibrillary acidic protein (GFAP.) This patient’s neuropathic pain likely represented a central pain syndrome due to the spinal and medullary degeneration. Our case illustrates that neuropathic pain may be a presenting symptoms of Alexander’s disease, and the importance of a broad differential in the workup of a common referral complaint.Disclosure: Dr. Massa has nothing to disclose. Dr. Beaber has nothing to disclose. Dr. Bronstein has nothing to disclose.

Source: Neurology - April 17, 2017 Category: Neurology Authors: Massa, J., Beaber, B., Bronstein, Y. Tags: General Neurology: The Eyes Have It and White Matter Matters Source Type: research