Pharmacological Therapy of Abdominal Aortic Aneurysm: An Update.

Pharmacological Therapy of Abdominal Aortic Aneurysm: An Update.
Curr Vasc Pharmacol. 2017 Apr 13;:
Authors: Wang YD, Liu ZJ, Ren J, Xiang MX
Abstract
Abdominal aortic aneurysm (AAA), a progressive segmental abdominal aortic dilation, is associated with high mortality. AAA is characterized by inflammation, smooth muscle cell (SMC) depletion and extracellular matrix (ECM) degradation. Surgical intervention and endovascular therapy are recommended to prevent rupture of large AAAs. Unfortunately, there is no reliable pharmacological agent available to limit AAA expansion. In the past decades, extensive investigations and a body of ongoing clinical trials aimed at defining potent treatments to inhibit and even regress AAA growth. In this review, we summarized recent progress of potential strategies, particularly macrolides, tetracyclines, statins, angiotensin converting enzyme inhibitors, angiotensin receptor blocker, corticosteroid, anti-platelet drugs and mast cell stabilizers. We also consider recently identified novel molecular targets, which have potential to be translated into clinical practice in the future.
PMID: 28412911 [PubMed - as supplied by publisher]

Source: Current Vascular Pharmacology - April 13, 2017 Category: Drugs & Pharmacology Authors: Wang YD, Liu ZJ, Ren J, Xiang MX Tags: Curr Vasc Pharmacol Source Type: research