Acute refractory intestinal pseudo-obstruction in MELAS: Efficacy of prucalopride

In mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS), a multisystem mitochondrial disorder, gastrointestinal involvement is frequent with dysphagia, chronic diarrhea, anorexia, abdominal pain, delayed gastric emptying, and paralytic, often intractable, ileus.1 In this article, we report a patient with chronic gastrointestinal dysmotility and acute refractory intestinal pseudo-obstruction responsive to prucalopride.

Source: Neurology - May 26, 2014 Category: Neurology Authors: Primiano, G., Plantone, D., Forte, F., Sauchelli, D., Scaldaferri, F., Gasbarrini, A., Servidei, S. Tags: CT, Mitochondrial disorders; see Genetics/Mitochondrial disorders, Muscle disease, Class IV, Mitochondrial disorders CLINICAL/SCIENTIFIC NOTES Source Type: research