Amyotrophic lateral sclerosis: MRI

Case Report:35 yr old lady referred for altered behavior , suggests  a possible "Wineglass " appearance of symmetrical T2 hyper intensity along the internal capsules, brainstem , with rest of the corticospinal tracts grossly unremarkable at present.  Further investigation including clinical, EMG& Lab data correlation is  being planned .Teaching points by Dr MGK Murthy1.  This greek word is completely self explanatory A (Negative) Myo (Muscle)  Trophic (Nourishment)   Lateral (spinal cord lateral parts involved) Sclerosis (Terminal degree of degeneration = Scarring )2. Other names include , Lou Gehring ( Named after ,famous Basket ball player victim) and Charcot disease.(responsible for initial description of Anterior horn cells of spinal cord ,being etiology for the disease) 3.  A variety of Motor neuron disease( poor prognosis ,average survival of 3-5 years) of Upper Motor neuron (giant pyramidal variety (BETZ) cells of motor cortex) and Lower Motor neuron ( including anterior horn cells of spinal cord) degeneration(basic pathology is Wallerian degeneration)4. 40-60 yrs usual age with 2 different patterns (a) familial (genetic mutations) (b) Sporadic (unknown, and may be genetic+ environmental). MRI shows  symmetrical T2 hyper intensity of corti...
Source: Sumer's Radiology Site - Category: Radiology Authors: Source Type: blogs