(196) Role of HMGB1 and TLR4 receptor in a chronic stress-induced pain model in rats

Stress-induced pain is a recognized but misunderstood phenomenon. In humans, exposure to chronic stress reduces the pain threshold resulting in an increase in hypersensitivity. In this sense, stress is known to exacerbate the etiology of various pathologies such as fibromyalgia, irritable bowel syndrome and rheumatoid arthritis. However, the mechanisms by which they are related are unknown. Previous studies have suggested the participation of the high mobility group B 1 (HMGB1) protein in inflammatory and neuropathic pain.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research