Non-major bleeding with apixaban versus warfarin in patients with atrial fibrillation

Conclusions
In ARISTOTLE, non-major bleeding was common and substantially less frequent with apixaban than with warfarin. CRNM bleeding was independently associated with a higher risk of death and subsequent major bleeding. Our results highlight the importance of any severity of bleeding in patients with AF treated with anticoagulation therapy and suggest that non-major bleeding, including minor bleeding, might not be minor.

Trial registration number
NCT00412984; post-results.

Source: Heart - March 28, 2017 Category: Cardiology Authors: Bahit, M. C., Lopes, R. D., Wojdyla, D. M., Held, C., Hanna, M., Vinereanu, D., Hylek, E. M., Verheugt, F., Goto, S., Alexander, J. H., Wallentin, L., Granger, C. B. Tags: Open access, Drugs: cardiovascular system Arrhythmias and sudden death Source Type: research