Signalling Mechanisms Underlying Doxorubicin And Nox2 Nadph Oxidase ‐Induced Cardiomyopathy: Involvement Of Mitofusin‐2

Conclusions and implicationsDOX‐induced and Nox2‐mediated upregulation of Mfn2, rather than contributing to cardiomyocyte dysfunction through apoptotic pathways, appears to promote a protective mechanism.

Source: British Journal of Pharmacology - March 5, 2017 Category: Drugs & Pharmacology Authors: Declan McLaughlin, Youyou Zhao, Karla M O'Neill, Kevin S Edgar, Philip D Dunne, Anna M Kearney, David J Grieve, Barbara J McDermott Tags: RESEARCH PAPER THEMED ISSUE Source Type: research