Technical approaches to induce selective cell death of pluripotent stem cells.
Technical approaches to induce selective cell death of pluripotent stem cells.
Cell Mol Life Sci. 2017 Feb 28;:
Authors: Jeong HC, Cho SJ, Lee MO, Cha HJ
Abstract
Despite the recent promising results of clinical trials using human pluripotent stem cell (hPSC)-based cell therapies for age-related macular degeneration (AMD), the risk of teratoma formation resulting from residual undifferentiated hPSCs remains a serious and critical hurdle for broader clinical implementation. To mitigate the tumorigenic risk of hPSC-based cell therapy, a variety of approaches have been examined to ablate the undifferentiated hPSCs based on the unique molecular properties of hPSCs. In the present review, we offer a brief overview of recent attempts at selective elimination of undifferentiated hPSCs to decrease the risk of teratoma formation in hPSC-based cell therapy.
PMID: 28246701 [PubMed - as supplied by publisher]
Source: Cellular and Molecular Life Sciences : CMLS - Category: Cytology Authors: Jeong HC, Cho SJ, Lee MO, Cha HJ Tags: Cell Mol Life Sci Source Type: research
More News: Age-Related Macular Degeneration (AMD) | Clinical Trials | Cytology | Stem Cell Therapy | Stem Cells | Teratoma