Captopril does not Potentiate Post-Exercise Hypotension: A Randomized Crossover Study
Int J Sports Med DOI: 10.1055/s-0042-123044To evaluate whether captopril (3×50 mg/day) potentiates post-resistance exercise hypotension (PREH) in hypertensives (HT), 12 HT men received captopril and placebo for 4 weeks each in a double-blinded, randomized-crossover design. On each therapy, subjects underwent 2 sessions: Control (C – rest) and Resistance Exercise (RE – 7 exercises, 3 sets to moderate fatigue, 50% of 1 RM –repetition maximum). Measurements were taken before and after 30–60 min (Post1) and 7 h (Post2), and ambulatory blood pressure (BP) was monitored for 24 h. There were no differences in PREH characteristics and mechanisms between the placebo and captopril periods. At Post1, systolic/diastolic BP decreased significantly and similarly after RE with both therapies (Placebo=−13±2/−9±1 mmHg vs. Captopril=−12±2/−10±1 mmHg, P<0.05). RE reduced cardiac output in some subjects and systemic vascular resistance in others. Heart rate and cardiac sympathetic modulation increased, while stroke volume and baroreflex sensitivity decreased after RE (Placebo: +13±2 bpm, +21±5 nu, −11±5 ml, −4±2 ms/mmHg; Captopril: +13±2 bpm, +35±4 nu, 17±5 ml, −3±1 ms/mmHg, P<0.05). At Post2, all variables returned to pre-intervention values. Ambulatory BP was similar between the sessions. Thus, captopril did not potentiate the magnitude and duration of PREH in HT men, and it did not influence PREH mechanisms. [...] © Georg Thiem...
Source: International Journal of Sports Medicine - Category: Sports Medicine Authors: Queiroz, Andr éia Cristiane Carrenho Sousa, Julio Cesar Silva Silva, Natan Daniel Tobaldini, Eleonora Ortega, Katia Coelho de Oliveira, Edilamar Menezes Brum, Patricia Chakur Montano, Nicola Mion, Decio Tinucci, Ta ís de Moraes Forjaz, Claudia Lucia Tags: Physiology & Biochemistry Source Type: research
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