Postmenopausal hormone therapy exceeding ten years may protect from dementia

(University of Eastern Finland) Postmenopausal estrogen-based hormone therapy lasting longer than ten years was associated with a decreased risk of Alzheimer's disease in a large study carried out at the University of Eastern Finland. The study explored the association between postmenopausal hormone replacement therapy, Alzheimer's disease, dementia and cognition in two nation-wide case-control studies and two longitudinal cohort studies. The largest study comprised approximately 230,000 Finnish women and the follow-up time in different studies was up to 20 years.
Source: EurekAlert! - Social and Behavioral Science - Category: Global & Universal Source Type: news

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Publication date: August 2018Source: The Lancet Neurology, Volume 17, Issue 8Author(s): Susana Carmona, Kathleen Zahs, Elizabeth Wu, Kelly Dakin, Jose Bras, Rita GuerreiroSummaryAlzheimer's disease is a genetically complex disorder; rare variants in the triggering receptor expressed on myeloid cells 2 (TREM2) gene have been shown to as much as triple an individual's risk of developing Alzheimer's disease. TREM2 is a transmembrane receptor expressed in cells of the myeloid lineage, and its association with Alzheimer's disease supports the involvement of immune and inflammatory pathways in the cause of the disease, rather th...
Source: The Lancet Neurology - Category: Neurology Source Type: research
Publication date: Available online 18 July 2018Source: Alzheimer's &DementiaAuthor(s): R. Laforce, J.P. Soucy, L. Sellami, C. Dallaire-Théroux, F. Brunet, D. Bergeron, B.L. Miller, R. OssenkoppeleAbstractMolecular imaging techniques using 18F-fluorodeoxyglucose, amyloid tracers, and, more recently, tau ligands have taken dementia research by storm and undoubtedly improved our understanding of neurodegenerative diseases. The ability to image in vivo the pathological substrates of degenerative diseases and visualize their downstream impact has led to improved models of pathogenesis, better differential diagno...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
People living with Alzheimer's and dementia are well known for their challenging and often difficult behaviors.By Bob DeMarcoAlzheimer's Reading RoomWhat can you do about it?Dementia Care, Do You Need to Change?Listen Now or Continue Reading BelowHow to Change Patterns of Behavior in Alzheimer's and Dementia PatientsThe following articles broaden the scope of the podcast; and, should help you to deal with the difficult behaviors you are dealing with each day.1. 7 Ways To Deal With Difficult Behavior Caused By Alzheimer's and DementiaPersons living with Alzheimer's or a related dementia are well known for their ch...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: Alzheimer's family alzheimers and dementia alzheimers education and training alzheimers podcast care of dementia patients dementia care at home help alzheimer's help with dementia care Source Type: blogs
She told us that she used to want to run her head into a brick wall when her mother started repeating the same story over and over.By Tom and Karen BrennerAlzheimer's Reading RoomThere is wonderful little tea shop that opened near us, and I have been visiting it with friends regularly.A month or so ago, I met an old acquaintance there; she wanted to learn more about the work that Tom and I do using the Montessori Method to help people living with Alzheimer ’s.Her mother was recently diagnosed with Alzheimer ’s and she wanted to get some tips on how to better help her mom.Empathy, Compassion and Joy in Alzheimer...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: Alzheimer's disease alzheimer's story alzheimers alzheimers caregiving Alzheimers Dementia health memory loss tea Source Type: blogs
Publication date: Available online 17 July 2018Source: NeuroImage: ClinicalAuthor(s): Christopher M. Weise, Kewei Chen, Yinghua Chen, Xiaoying Kuang, Cary R. Savage, Eric M. Reiman, Alzheimer's Disease Neuroimaging InitiativeAbstractBackgroundPrevious publications indicate that Alzheimer's Disease (AD) related cortical atrophy may develop in asymmetric patterns, with accentuation of the left hemisphere. Since fluorodeoxyglucose positron emission tomography (FDG PET) measurements of the regional cerebral metabolic rate of glucose (rCMRgl) provide a sensitive and specific marker of neurodegenerative disease progression, we s...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Publication date: August 2018Source: Neuropsychologia, Volume 117Author(s): Béatrice Garcin, Emmanuelle Volle, Aurélie Funkiewiez, Bruce L. Miller, Bruno Dubois, Richard LevyAbstractBackgroundPatients with neurodegenerative diseases affecting the frontal lobes have difficulties in categorization tasks, such as the similarity tasks. They give two types of unusual response to the question: “In what way are an orange and a banana alike?”, either a differentiation (“one is yellow, the other is orange”) or a concrete similarity (“they are sweet”).ObjectiveTo characterize the cat...
Source: Neuropsychologia - Category: Neurology Source Type: research
Clearance of metabolic waste from the brain via fluid drainage pathways is becoming an important topic in the context of age-related neurodegeneration, as is noted by the authors of this open access review paper. There is good evidence to suggest that drainage of cerebrospinal fluid is a significant path for the removal of wastes, such as the protein aggregates associated with dementia, and that the relevant fluid channels atrophy and fail with age. That decline may well be an important contribution to the development of neurodegenerative disease in later life, and the first efforts to do something about it are now underwa...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Pure Alzheimer's Disease (AD) pathology has been recognized as the most frequent underlying pathology in non-amnestic Mild Cognitive Impairment (naMCI) (Schneider  et al., 2009). Supporting this data, Dugger et al. (2015) found that neurofibrillary tangles, neuritic plaques and Lewy Bodies loads were similar in persons with amnestic MCI (aMCI) and naMCI, with the temporal lobe showing a differential propensity of neurofibrillary tangles for aMCI and of L ewy-type alpha-synucleinopathy for naMCI. Conversely, naMCI has been associated with cerebrovascular disease more often than aMCI (Hughes et&...
Source: Psychiatry Research - Category: Psychiatry Authors: Source Type: research
This study was supported by the Fran and Ray Stark Foundation Fund for Alzheimer ’s Disease Research; the Parlow-Solomon and Plot Professorships; Bob and Marion Wilson; the Ahmanson Foundation; the National Institutes of Health; and the Department of Energy.The FDDNP tracer is intellectual property owned by UCLA and licensed to TauMark LLC. Barrio, Huang, Omalu, Satyamurthy and Small are co-inventors of the marker. Barrio, Fitzsimmons, Huang, Satyamurthy and Small have a financial interest in TauMark. Other disclosures are listed in the study.
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Researchers from Yale University are reporting promising results with a PET...Read more on AuntMinnie.comRelated Reading: Are amyloid PET scans ready for the clinical setting? PET links amyloid, vascular factors to cognitive decline PET with novel tracers foretells early Alzheimer's risk PiB-PET study strengthens link between amyloid, dementia High amyloid levels on PET may indicate early Alzheimer's
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
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