Randomised controlled trial examining the effect of an outpatient exercise training programme on haemodynamics and cardiac MR parameters of right ventricular function in patients with pulmonary arterial hypertension: the ExPAH study protocol
This study will assess the effect of an outpatient rehabilitation programme on haemodynamics and cardiac right ventricular function in patients with pulmonary arterial hypertension (PAH), a subgroup of PH.
Methods and analysis
This randomised controlled trial involves both a major urban tertiary and smaller regional hospital in New South Wales, Australia. The intervention will compare an outpatient rehabilitation programme with a control group (home exercise programme). Participants will be stable on oral PAH-specific therapy. The primary outcome measure will be right ventricular ejection fraction measured by cardiac MRI. Secondary outcomes will include haemodynamics measured by right heart catheterisation, endurance, functional capacity, health-related quality of life questionnaires and biomarkers of cardiac function and inflammation.
Ethics approval and dissemination
Ethical approval has been granted by St Vincent's Hospital, Sydney (HREC/14/SVH/341). Results of this study will be disseminated through presentation at scientific conferences and in scientific journals.
Trial registration number
ACTRN12615001041549; pre-results.
Source: BMJ Open - Category: Journals (General) Authors: Chia, K. S. W., Faux, S. G., Wong, P. K. K., Holloway, C., Assareh, H., McLachlan, C. S., Kotlyar, E. Tags: Open access, Cardiovascular medicine, Rehabilitation medicine, Respiratory medicine Protocol Source Type: research
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