Effects on Metabolites of Dietary Sodium: The Dietary Approaches to Stop Hypertension (DASH)-Sodium Feeding Study

We report relations between metabolic pathways and low sodium intake by combining individual metabolite P values with the use of Fisher’s exact test. Of the 36 metabolic pathways tested, 6 were associated with sodium intake, with a P value <0.005 (i.e., benzoate, tryptophan, plant components, -glutamyl amino acid, fatty acid, and methionine metabolism). Of the 681 named metabolites tested, 82 were associated with sodium intake at a false discovery rate <0.2. The metabolites with the strongest associations, independent of blood pressure, were 4-ethylphenysulfate and 4-hydroxyphenylpyruvate, which increased, and isovalerate -glutamyl-isoleucine, -glutamyl-valine, and -glutamyl-leucine, which decreased with low sodium consumption (P < 0.00008). Sodium intake not only affects blood pressure but also concentrations of metabolites within the blood.
Source: Advances in Nutrition - Category: Nutrition Authors: Tags: Variability in Responses to Diet and Food Source Type: research