Oral Vancomycin Followed by Fecal Transplantation Versus Tapering Oral Vancomycin Treatment for Recurrent Clostridium difficile Infection: An Open-Label, Randomized Controlled Trial

Conclusions.
In patients experiencing an acute episode of recurrent CDI, a single FT by enema was not significantly different from oral vancomycin taper in reducing recurrent CDI. Further research is needed to explore optimal donor selection, FT preparation, route, timing, and number of administrations.

Clinical Trials Registration.
NCT01226992.

Source: Clinical Infectious Diseases - January 16, 2017 Category: Infectious Diseases Authors: Hota, S. S., Sales, V., Tomlinson, G., Salpeter, M. J., McGeer, A., Coburn, B., Guttman, D. S., Low, D. E., Poutanen, S. M. Tags: Major Article Source Type: research