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High-risk patient gets life-saving transplant when UCLA team accepts her case

A 24-year-old cystic fibrosis patient is starting the new year with new hope thanks to help from the U.S. Air Force, the actor who played Chewbacca in the “Star Wars” movies and a UCLA surgeon who said yes to a high-risk case.Kathlyn Chassey of San Antonio, Texas, was born with cystic fibrosis, a genetic disease characterized by the build-up in the lungs of thick, sticky mucus that traps infection-causing bacteria. While there is no cure, lung transplantation can help alleviate many of the symptoms.Courtesy of the Chassey familyKathlyn Chassey walks after her lung transplant surgery at Reagan UCLA Medical Center.Chassey ’s father, Chris, is a chief master sergeant in the United States Air Force. Last November, when her breathing problems worsened, she was hospitalized at the Brooke Army Medical Center in San Antonio. By the end of the month, her condition became critical, and she was placed on life support to tak e over her breathing function.The only chance of saving her life, doctors warned, was a lung transplant.An urgent search began to find a transplant center that would take her case. But one center after another turned her down, deeming the surgery too risky.With time running out, Chassey ’s family desperately needed help spreading the word. Friends quickly developed a website and social media campaign. As members of the "Star Wars" fandom, the family turned to longtime friend, actor Peter Mayhew — Chewbacca from the films &...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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In this study we investigated regulatory t cells after combined lung and liver transplantation, or after isolated lung transplantation, in cystic fibrosis patients and correlated the findings with long term outcomes
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Patients with cystic fibrosis (CF) may have pulmonary infection with multi-drug resistant organisms (MDRO) potentially impacting post-transplant mortality. Our objective was to study 1-year mortality in CF patients with MDRO compared to those without MDRO lung transplant recipients (LTR) querying the largest international registry.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Early detection of Mycobacterium abscessus complex (MABSC) is crucial for patients with chronic lung disease to enhance the opportunity for potential eradication. Colonisation with MABSC is an absolute contra indication to lung transplantation in many transplant centres. Isolation of MABSC and other non-tuberculous mycobacteria (NTM) by traditional AFB culture is problematic, particularly from patients with cystic fibrosis (CF). Cultures are frequently overgrown by other bacteria or fungi and sputum decontamination procedures can reduce the viability of NTM.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Lobar lung transplantation is known as an alternative for higher Donor/Receiver mismatch in cystic fibrosis or idiopathic pulmonary fibrosis patients. Using lobar lung transplantation for Pulmonary Hypertension remains questionable because of the higher risk of primary graft dysfunction. We thought to determine wether lobar lung transplantation from brain-dead donors is an option for Pulmonary Hypertension.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
This study aims to characterize this acute airway inflammation in association with ACR status.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
We report our experience of LTx for CF patients infected with BCC.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Achromobacter colonization of cystic fibrosis (CF) patients is deemed to be associated with higher risk of graft loss and the rods are usually defined as multi or pan resistant. We aimed to evaluate if CF patients transplanted with previous Achromobacter colonization had worst clinical outcome post lung transplantation.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Lung transplantation (LTX) is the ultimate therapy for end-stage cystic fibrosis (CF) lung disease; however, morbidity and mortality are considerable. CF patients achieve the best overall outcome post LTX. We investigated a subgroup of CF-patients and a minimum of 10 years post-LTX survival, aiming to determine possible predictors of long-term survival and characterize comorbidities.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
 >>>Available Here with Free Look Inside Option Correct answer: 3. Both 1 and 2 In domino heart transplantation, the donor receives heart lung transplantation. The excised heart is transplanted to another recipient so that the donor for recipient of domino heart transplantation is alive, unlike the conventional donor who is brain dead. In one report of 10 cases of domino heart transplantation, one year survival of donor was 60% while that of recipient was 90% [1]. It worthwhile noting that donors had terminal cardio pneumopathy (mostly primary pulmonary hypertension, one case of Eisenmenger syndrome and ...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
Discussion Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane receptor (CFTR). It is found in the epithelium of the bronchi, intestine, pancreatic duct and biliary tree. It regulates chloride, bicarbonate and water secretion. The heterozygous state helps prevent against secretory diarrhea, but the homozygous state causes thickened secretions in the hollow tubes of the lungs and digestive tract. There are multiple mutations (> 2000) which have been currently classified into classes depending on their protein production and activity. CF patients generally are l...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
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