Loss of osteoglycin promotes angiogenesis in limb ischaemia mouse models via modulation of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 signalling pathway

Conclusions OGN plays a critical role in negatively regulating ischaemia-induced angiogenesis by inhibiting VEGF–VEGFR2 signalling and thereby attenuating EC tube formation, proliferation, and migration. Thus, OGN may be a novel therapeutic target for ischaemic vascular diseases.

http://cardiovascres.oxfordjournals.org/cgi/content/short/113/1/70?rss=1

Source: Cardiovascular Research - January 8, 2017 Category: Cardiology Authors: Wu, Q.-H., Ma, Y., Ruan, C.-C., Yang, Y., Liu, X.-H., Ge, Q., Kong, L.-R., Zhang, J.-W., Yan, C., Gao, P.-J. Tags: Vascular biology Source Type: research